The art of being human : a project for general philosophy of science

Throughout the medieval and modern periods, in various sacred and secular guises, the unification of all forms of knowledge under the rubric of ‘science’ has been taken as the prerogative of humanity as a species. However, as our sense of species privilege has been called increasingly into question, so too has the very salience of ‘humanity’ and ‘science’ as general categories, let alone ones that might bear some essential relationship to each other. After showing how the ascendant Stanford School in the philosophy of science has contributed to this joint demystification of ‘humanity’ and ‘science’, I proceed on a more positive note to a conceptual framework for making sense of science as the art of being human. My understanding of ‘science’ is indebted to the red thread that runs from Christian theology through the Scientific Revolution and Enlightenment to the Humboldtian revival of the university as the site for the synthesis of knowledge as the culmination of self-development. Especially salient to this idea is science‘s epistemic capacity to manage modality (i.e. to determine the conditions under which possibilities can be actualised) and its political capacity to organize humanity into projects of universal concern. However, the challenge facing such an ideal in the twentyfirst century is that the predicate ‘human’ may be projected in three quite distinct ways, governed by what I call ‘ecological’, ‘biomedical’ and ‘cybernetic’ interests. Which one of these future humanities would claim today’s humans as proper ancestors and could these futures co-habit the same world thus become two important questions that general philosophy of science will need to address in the coming years

The Astronomy of the Kamilaroi People and their Neighbours

The Kamilaroi people and their neighbours, the Euahlayi, Ngemba, and Murrawarri, are an Aboriginal cultural grouping located in the northwest and north central of New South Wales. They have a rich history, but have been missed in much of the literature concerned with sky knowledge in culture. This study collected stories, some of which have not previously been reported in an academic format, from Aboriginal people practicing their culture, augmented with stories from the literature, and analysed the data to create a database of sky knowledge that will be added to the larger body of Aboriginal cultural knowledge in Australia. We found that there is a strong sky culture reflected in the stories, and we also explored the stories for evidence of an ethnoscientific approach to knowledge of the sky.Comment: 28 pages, 9 figure

Support of ASTP/KOSMOS fundulus embryo development experiment

Results from the Kosmos Biosatellite 782 flight are presented. Experiments with fish hatchlings are discussed along with postflight observation and testing. The preparation of fertilized eggs for the experiments is described

Cartan Triples

We introduce the class of Cartan triples as a generalization of the notion of a Cartan MASA in a von Neumann algebra. We obtain a one-to-one correspondence between Cartan triples and certain Clifford extensions of inverse semigroups. Moreover, there is a spectral theorem describing bimodules in terms of their support sets in the fundamental inverse semigroup and, as a corollary, an extension of Aoi's theorem to this setting. This context contains that of Fulman's generalization of Cartan MASAs and we discuss his generalization in an appendix.Comment: 37 page

Interdistrict Choice and Teacher Beliefs: Implications for Educational Expectations, Equity, and Policymaking

Interdistrict choice, which allows families to choose between schools outside of their districts of residence, is currently serving more students than any other choice program in the United States. Yet, despite this popularity, there is a pressing need for more research on how interdistrict choice may affect educational equity within U.S. public schools. Drawing on the analytic framework of educational racial contract, this study examines the issue of teacher beliefs in the context of interdistrict choice at a large, urban high school in Arizona, where market-based school choice programs have been continually expanded for nearly three decades. Data were collected through a survey of 112 teachers, who rated their in- district and out-of-district students based on their perception of three developmental skill categories: 1) academic, 2) communication, and 3) behavior. Results speak to negative teacher beliefs about the educability of Students of Color and hold significant implications for teachers’ academic expectations, educational equity, and future policy decisions

New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease

There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need. AD is characterized by episodic memory loss followed by severe cognitive decline and is associated with many neuropathological changes. AD is characterized by deposits of amyloid beta (A?), neurofibrillary tangles, and neuroinflammation. Active immunization or passive immunization against A? leads to the clearance of deposits in transgenic mice expressing human A?. This clearance is associated with reversal of associated cognitive deficits, but these results have not translated to humans, with both active and passive immunotherapy failing to improve memory loss. One explanation for these observations is that certain anti-A? antibodies mediate damage to the cerebral vasculature limiting the top dose and potentially reducing efficacy. Fc gamma receptors (Fc?R) are a family of immunoglobulin-like receptors which bind to the Fc portion of IgG, and mediate the response of effector cells to immune complexes. Data from both mouse and human studies suggest that cross-linking Fc?R by therapeutic antibodies and the subsequent pro-inflammatory response mediates the vascular side effects seen following immunotherapy. Increasing evidence is emerging that Fc?R expression on CNS resident cells, including microglia and neurons, is increased during aging and functionally involved in the pathogenesis of age-related neurodegenerative diseases. Therefore, we propose that increased expression and ligation of Fc?R in the CNS, either by endogenous IgG or therapeutic antibodies, has the potential to induce vascular damage and exacerbate neurodegeneration. To produce safe and effective immunotherapies for AD and other neurodegenerative diseases it will be vital to understand the role of Fc?R in the healthy and diseased brain. Here we review the literature on Fc?R expression, function and proposed roles in multiple age-related neurological diseases. Lessons can be learnt from therapeutic antibodies used for the treatment of cancer where antibodies have been engineered for optimal efficacy

Orientations of linear stone arrangements in New South Wales

We test the hypothesis that Aboriginal linear stone arrangements in New South Wales (NSW) are oriented to cardinal directions. We accomplish this by measuring the azimuths of stone arrangements described in site cards from the NSW Aboriginal Heritage Information Management System. We then survey a subset of these sites to test the accuracy of information recorded on the site cards. We find a preference recorded in the site cards for cardinal orientations among azimuths. The field surveys show that the site cards are reasonably accurate, but the surveyors probably did not correct for magnetic declinations. Using Monte Carlo statistics, we show that these preferred orientations did not occur by chance and that Aboriginal people deliberately aligned these arrangements to the approximate cardinal directions. We briefly explore possible reasons for these preferred orientations and highlight the need for future work.Comment: Australian Archaeology, Volume 75 (December 2012), accepte

CARTAN TRIPLES

We introduce the class of Cartan triples as a generalization of the notion of a Car- tan MASA in a von Neumann algebra. We obtain a one-to-one correspondence between Cartan triples and certain Clifford extensions of inverse semigroups. Moreover, there is a spectral theorem describing bimodules in terms of their support sets in the fundamental inverse semigroup and, as a corollary, an extension of Aoi’s theorem to this setting. This context contains that of Fulman’s generalization of Cartan MASAs and we discuss his generalization in an appendix